Invited Review HIGHLIGHTED TOPIC Oxygen Sensing in Health and Disease Hyperoxia, reactive oxygen species, and hyperventilation: oxygen sensitivity of brain stem neurons
نویسندگان
چکیده
Jay B. Dean, Daniel K. Mulkey, Richard A. Henderson III, Stephanie J. Potter, and Robert W. Putnam Department of Anatomy and Physiology, Environmental and Hyperbaric Cell Biology Facility, Wright State University School of Medicine, College of Science and Mathematics, Dayton, Ohio 45435; and Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814
منابع مشابه
Hyperoxia, reactive oxygen species, and hyperventilation: oxygen sensitivity of brain stem neurons.
Hyperoxia is a popular model of oxidative stress. However, hyperoxic gas mixtures are routinely used for chemical denervation of peripheral O2 receptors in in vivo studies of respiratory control. The underlying assumption whenever using hyperoxia is that there are no direct effects of molecular O2 and reactive O2 species (ROS) on brain stem function. In addition, control superfusates used routi...
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Objective(s):Gentamicin sulphate (GS) nephrotoxicity seems to be related to the generation of reactive oxygen species. There is evidence that oxygen preconditioning increases the activity of antioxidant enzymes. Materials and Methods: Forty eight female rats were divided into 6 groups (n=8) as follows: group 1 was the control, group 2 received daily GS, groups 3,4 and 5 received oxygen 2 hr/day...
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Cherniack, Neil S. Oxygen sensing: applications in humans. J Appl Physiol 96: 352–358, 2004; 10.1152/japplphysiol.00755.2003.—Our concepts of oxygen sensing have been transformed over the years. We now appreciate that oxygen sensing is not a unique property limited to “chemoreceptors” but is a common property of tissues and that responses to changes in oxygen levels are not static but can chang...
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Hyperoxia, a model of oxidative stress, can disrupt brain stem function, presumably by an increase in O2 free radicals. Breathing hyperbaric oxygen (HBO2) initially causes hyperoxic hyperventilation, whereas extended exposure to HBO2 disrupts cardiorespiratory control. Presently, it is unknown how hyperoxia affects brain stem neurons. We have tested the hypothesis that hyperoxia increases excit...
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